[Biopurify 한국공식대리점] Cyclopamine

[Biopurify 한국공식대리점] Cyclopamine

[Cyclopamine]

 

Product Information:

• Product name: Cyclopamine
• Catalogue No.: BP0437
• Cas No.: 4449-51-8
• Formula: C27H41NO2
• Mol Weight: 411.63
• Botanical Source: Veratrum californicum and Veratrum album (Liliaceae)
• Purity: >99%
• Analysis Method: HPLC-DAD or/and HPLC-ELSD
• Identification Method: Mass, NMR
• Packing: Brown vial or HDPE plastic bottle

Cyclopamine (11-deoxojervine) is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). Cyclopamine does so by inhibiting the hedgehog signaling pathway (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
 

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